The latest editorials coverage from Hawaii Medical Journal.
A multicenter randomized trial demonstrates that deferring arterial catheterization in hemodynamically stable patients with shock reduces complications without compromising clinical outcomes. The findings challenge current intensive care practices regarding invasive monitoring protocols.
A multicenter randomized controlled trial demonstrates notable efficacy outcomes for dual-targeted therapy in EGFR-mutated advanced NSCLC, though several methodological considerations warrant examination.
A first-in-class small-molecule inverse agonist of peroxisome proliferator-activated receptor gamma achieved objective responses in 17.5% of patients with urothelial carcinoma in a phase 1 dose-escalation study. The agent exhibited acceptable tolerability with grade 3 or higher adverse events primarily consisting of hematologic toxicities.